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KMID : 0378120020290010207
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Chungnam Medical Journal
2002 Volume.29 No. 1 p.207 ~ p.215
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The Effect of Tibolone on BMD in Postmenopausal Women with Osteopenia
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Kang Kil-Chun
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Abstract
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To investigate the effects of tibolone on trabecular and cortical bone mineral density (BMD) in postmenopausal women with osteopenia, a 2-year, randomized, double-blind, placebo-controlled study was tried. 36 women were treated with tibolone as study group and 31 with calcium as control group. Trabecular BMD of lumbar spine(L1 to L4) and cortical BMD at the femoral neck were assessed by dual energy x-ray absorptiometry at baseline and at 6-month intervals. After 2 years, subjects in the tibolone group gained 7.9% bone mass at lumbar spine and 4.5% at femoral neck, and respective increases from baseline in the placebo group were 3.5% and 2.0%. Tibolone-treated patients gained statistically significantly more bone mass than placebo-treated patients in the spine and femur. This study showed that Tibolone induced a significant increase in trabecular (lumbar spine) and cortical (femoral neck) bone mass in postmenopausal osteopenic women compared to placebo.
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KEYWORD
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Tibolone, Osteopenia, Bone mineral denity
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